Central to Perone's practice is humanity's relationship with the natural world, and his work addresses themes around the body, nature, time, touch and memory. Perone makes use of a variety of natural materials including stone, acacia thorns and laurel leaves. An ongoing motif throughout his work is the importance of trees to society.
One suggestion of this is through Matrice, which consists of a 30 metre long bisected trunk of a fir tree that has been laid horizontally and carefully carved to follow one of its growth rings. The trunk cuts through the separate rooms within the gallery so as to emphasise the shear size of the object and to reflect the way that the tree itself has been sliced and examined.